Lirilumab

Drug Profile

Lirilumab

Alternative Names: Anti-KIR (1-7F9); Anti-KIR monoclonal antibody - Innate Pharma; BMS-986015; IPH-21; IPH-2101; IPH-2102; LIRI; NN 1975

Latest Information Update: 12 Dec 2016

Price : $50

At a glance

  • Originator Novo Nordisk
  • Developer Bristol-Myers Squibb; Innate Pharma; National Cancer Institute (USA); University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action KIR receptor antagonists; Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Myelodysplastic syndromes
  • Phase I Haematological malignancies; Multiple myeloma; Solid tumours
  • Preclinical Lymphoma
  • Discontinued Hepatitis C

Most Recent Events

  • 05 Dec 2016 Interim efficacy data from a phase II trial in Acute myeloid leukaemia released by Innate Pharma
  • 12 Nov 2016 Efficacy data from expansion cohort of phase I/II trial in Solid tumours released by Bristol-Myers Squibb
  • 09 Nov 2016 Preliminary adverse events data from a phase I/II trial in Solid tumours presented at the 2016 European Society for Medical Oncology Congress (ESMO-2016).
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