Drug Profile


Alternative Names: Anti-KIR (1-7F9); Anti-KIR monoclonal antibody - Innate Pharma; BMS-986015; IPH-21; IPH-2101; IPH-2102; LIRI; NN 1975; ONO-4483

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Novo Nordisk
  • Developer Bristol-Myers Squibb; Innate Pharma; National Cancer Institute (USA); Ono Pharmaceutical; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action KIR receptor antagonists; Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chronic lymphocytic leukaemia; Myelodysplastic syndromes
  • Phase I/II Solid tumours
  • Phase I Haematological malignancies; Multiple myeloma
  • Preclinical Lymphoma
  • Discontinued Acute myeloid leukaemia; Hepatitis C

Most Recent Events

  • 05 Jul 2017 Phase-I clinical trials in Solid tumours (Inoperable/Unresectable, Metastatic disease, Combination therapy) in Japan (IV) (NCT03203876)
  • 28 Jun 2017 Bristol-Myers Squibb plans a phase I trial for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in Japan (NCT03203876)
  • 02 Jun 2017 Efficacy and adverse events data from a phase-II trial for Acute myeloid leukaemia (Combination therapy) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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