INT 767

Drug Profile

INT 767

Alternative Names: Dual FXR/TGR5 agonists - Intercept Pharmaceuticals; FXR & TGR5 BA-derived backups - Intercept Pharmaceuticals; INT-767

Latest Information Update: 22 Feb 2017

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At a glance

  • Originator Intercept Pharmaceuticals
  • Class Anti-inflammatories; Antifibrotics; Bile acids and salts; Cholanes; Small molecules; Sulfates
  • Mechanism of Action Farnesoid X-activated receptor agonists; G protein-coupled receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Hepatic fibrosis
  • Preclinical Diabetic nephropathies; Metabolic disorders; Non-alcoholic steatohepatitis

Most Recent Events

  • 04 May 2017 Intercept Pharmaceuticals plans a phase II trial for Non-alcoholic steatohepatitis in the second half of 2017
  • 11 Nov 2016 Preclinical trials in Non-alcoholic steatohepatitis in USA
  • 11 Nov 2016 Pharmacodynamics data from a preclinical study in Non-alcoholic steatohepatitis presented at the 67th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD-2016)
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