TC 6499

Drug Profile

TC 6499

Alternative Names: TC-6499; TC-6499-12

Latest Information Update: 20 Oct 2016

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At a glance

  • Originator Targacept
  • Developer GlaxoSmithKline; Targacept
  • Class Irritable bowel syndrome therapies; Non-opioid analgesics; Small molecules
  • Mechanism of Action Alpha3beta4 nicotinic receptor agonists; Alpha4beta2 nicotinic receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Diabetic gastroparesis; Irritable bowel syndrome; Neuropathic pain

Most Recent Events

  • 18 Oct 2016 Catalyst Biosciences enters into a definitive agreement with an undisclosed partner for the divestiture of its neuronal nicotinic receptor, TC 6499
  • 16 Apr 2015 Discontinued - Phase-I/II for Diabetic gastroparesis in USA (PO)
  • 16 Apr 2015 Targacept completes a phase I/II trial for Diabetic gastroparesis in USA
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