Ixazomib

Drug Profile

Ixazomib

Alternative Names: Ixazomib citrate; MLN-2238; MLN-9708; NINLARO

Latest Information Update: 12 Dec 2017

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At a glance

  • Originator Millennium Pharmaceuticals
  • Developer HOVON Foundation; Massachusetts General Hospital; National Cancer Institute (USA); Northside Hospital; Northwestern University; Takeda Oncology; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Organic boron compounds; Small molecules
  • Mechanism of Action Apoptosis stimulants; Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Amyloidosis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Multiple myeloma
  • Phase III Amyloid light-chain amyloidosis
  • Phase II Acute myeloid leukaemia; Amyloidosis; Follicular lymphoma; Haematological malignancies; Lymphoma; Myelodysplastic syndromes; Waldenstrom's macroglobulinaemia
  • Phase I/II Bladder cancer; Graft-versus-host disease; HIV infections
  • Phase I Acute lymphoblastic leukaemia; Lupus nephritis; Non-small cell lung cancer; Pancreatic cancer
  • Discontinued Solid tumours

Most Recent Events

  • 01 Nov 2017 Millennium Pharmaceuticals completes a phase III trial in Multiple myeloma (Combination therapy, Newly diagnosed, Maintenance therapy) in Spain (PO) (NCT02406144)
  • 01 Nov 2017 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease) in USA (PO) due to insufficient response observed , Takeda Q2 report 2017)
  • 01 Nov 2017 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) due to insufficient response observed , Takeda Q2 report 2017)
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