Drug Profile


Alternative Names: Chimeric Antibody (TRC105) to CD105; DE 122; NSC#754227; TRC-105

Latest Information Update: 20 Feb 2017

Price : $50

At a glance

  • Originator Roswell Park Cancer Institute
  • Developer National Cancer Institute (USA); Santen Pharmaceutical; TRACON Pharmaceuticals; University of Alabama at Birmingham
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action ENG protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Haemangiosarcoma
  • Phase II Choriocarcinoma; Glioblastoma; Hepatocellular carcinoma; Renal cell carcinoma; Soft tissue sarcoma
  • Phase I/II Breast cancer; Wet age-related macular degeneration
  • Phase I Non-small cell lung cancer
  • Preclinical Acute myeloid leukaemia; Colorectal cancer
  • Discontinued Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer

Most Recent Events

  • 10 May 2017 Santen Pharmaceutical plans the phase II AVANTE trial in combination with ranibizumab for Wet age-related macular degeneration (Combination therapy)
  • 13 Feb 2017 Phase-III clinical trials in Haemangiosarcoma (Late-stage disease; Second-line therapy or greater) in USA (IV) (NCT02979899)
  • 03 Jan 2017 TRACON Pharmaceuticals receives special protocol assessment from the US FDA for a pivotal phase III trial of Carotuximab for Haemangiosarcoma
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