BMS 833923

Drug Profile

BMS 833923

Alternative Names: BMS-833923; XL-139

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Exelixis
  • Developer Bristol-Myers Squibb; Exelixis
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Hedgehog cell-signalling pathway inhibitors; SMO protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chronic myeloid leukaemia
  • No development reported Gastrointestinal cancer; Multiple myeloma; Small cell lung cancer; Solid tumours

Most Recent Events

  • 01 Jan 2017 Bristol-Myers Squibb terminates a phase II trial as no participants enrolled in this trial could receive the recommended phase 2 dose in Chronic myeloid leukaemia (Newly diagnosed, First-line therapy, Combination therapy) in USA, Argentina, Belgium, Canada, Finland, France, Germany, Poland and Spain (NCT01357655)
  • 15 Dec 2016 Biomarkers information updated
  • 16 Jul 2016 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Metastatic disease) in Canada (PO, Capsule)
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