Drug Profile


Alternative Names: 1 MT; 1-methyl-D-tryptophan; 1-methyltryptophan; d-1-methyltryptophan; D-1MT; NLG-001; NLG-8189; NSC-721782

Latest Information Update: 12 Sep 2017

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At a glance

  • Originator Lankenau Institute for Medical Research
  • Developer National Cancer Institute (USA); NewLink Genetics Corporation; University of Minnesota
  • Class Amino acids; Antineoplastics; Indoles; Small molecules
  • Mechanism of Action Indoleamine-pyrrole 2,3-dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Non-small cell lung cancer; Prostate cancer
  • Phase I/II Acute myeloid leukaemia; Glioma; Malignant melanoma; Pancreatic cancer
  • Phase I Solid tumours

Most Recent Events

  • 07 Sep 2017 Updated safety and efficacy data from a phase II trial in Malignant melanoma released by NewLink Genetics
  • 31 Jul 2017 Efficacy data from a phase Ib/IIa trial for Acute myeloid leukaemia released by NewLink Genetics Corporation
  • 10 Jul 2017 NewLink Genetics Corporation receives patent allowance for indoximod in USA
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