Drug Profile


Alternative Names: ACT-1; Connexin-43 mimic - FirstString Research; Gap junction peptide - FirstString Research; Granexin Gel; Wound-healing peptide gel - FirstString Research

Latest Information Update: 05 Dec 2017

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At a glance

  • Originator FirstString Research; Medical University of South Carolina
  • Class Peptide fragments
  • Mechanism of Action Gap junction modulators; Tight junction protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Diabetic foot ulcer; Leg ulcer; Radiation injuries; Scars
  • Phase II/III Radiodermatitis
  • Preclinical Age-related macular degeneration; Corneal injuries
  • No development reported Fibrosis; Spinal cord injuries

Most Recent Events

  • 05 Dec 2017 Preclinical development for Corneal injuries and Age-related-macular-degeneration is underway in USA (Ophthalmic, Drops) (FirstString Research Pipeline, December 2017)
  • 04 Nov 2017 No recent reports of development identified for preclinical development in Age-related-macular-degeneration in USA (Ophthalmic, Drops)
  • 04 Nov 2017 No recent reports of development identified for preclinical development in Corneal injuries in USA (Ophthalmic, Drops)
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