Drug Profile


Alternative Names: Debio-0824; ShK-186

Latest Information Update: 25 Jul 2017

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At a glance

  • Originator Airmid; University of California at Irvine
  • Developer Kineta; KPI Therapeutics; Seattle Childrens Research Institute; University of California at Irvine; University of Groningen
  • Class Amides; Peptides; Proteins
  • Mechanism of Action Kv1.3 potassium channel inhibitors; T lymphocyte modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Plaque psoriasis; Psoriatic arthritis
  • Preclinical Inclusion body myositis; Lupus nephritis; Vasculitis
  • Research Inflammatory bowel diseases; Multiple sclerosis
  • No development reported Autoimmune disorders; Obesity

Most Recent Events

  • 22 May 2017 Preclinical trials in Inclusion body myositis in USA (SC), before May 2017
  • 22 May 2017 KPI Therapeutics plans proof of concept trials for Inclusion body myositis in USA, in 2017 (KPI Therapeutics website, July 2017)
  • 16 Jul 2016 No recent reports of development identified for phase-I development in Autoimmune-disorders(In volunteers) in Netherlands (SC, Injection)
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