Drug Profile


Alternative Names: AHU-377/valsartan; Entresto; LCZ-696; LCZ-696A; Neparvis; Valsartan/AHU-377; Valsartan/sacubitril

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Novartis
  • Class Antihypertensives; Biphenyl compounds; Branched-chain amino acids; Esters; Heart failure therapies; Pentanoic acids; Small molecules; Tetrazoles
  • Mechanism of Action Angiotensin type 1 receptor antagonists; Neprilysin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Heart failure
  • Phase III Essential hypertension; Hypertension; Kidney disorders

Most Recent Events

  • 18 Mar 2017 Efficacy data from a post-hoc analysis of the phase III PARADIGM-HF trial in Heart failure released by Novartis
  • 08 Mar 2017 Novartis plans a phase III trial for Heart failure (NCT03066804)
  • 01 Mar 2017 Novartis completes the UK HARP-III phase III trial in Kidney disorders (chronic kidney disease) in United Kingdom (ISRCTN11958993)
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