Drug Profile


Alternative Names: CKD-943; CR 845; FE 202845; MR13A9

Latest Information Update: 28 Jul 2017

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At a glance

  • Originator Ferring Pharmaceuticals
  • Developer Cara Therapeutics; Chong Kun Dang; Maruishi Pharmaceutical
  • Class Opioid analgesics; Peptides
  • Mechanism of Action Opioid kappa receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Postoperative pain; Pruritus
  • Phase II Pain

Most Recent Events

  • 03 Aug 2017 Cara Therapeutics announces intention to submit IND for oral difelikefalin in Chronic liver disease-associated pruritus in the fourth quarter of 2017
  • 03 Aug 2017 Cara Therapeutics plans a phase I trial for oral difelikefalin in Chronic kidney disease-associated pruritus (non-haemodialysis patients) in the fourth quarter of 2017
  • 03 Aug 2017 Cara Therapeutics plans a phase III pivotal trial for Chronic kidney disease-associated pruritus in haemodialysis patients in fourth quarter of 2017
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