Drug Profile


Alternative Names: Adelatinib; VRT-831509; VX-509

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Vertex Pharmaceuticals
  • Class Amides; Aminopyridines; Anti-inflammatories; Antirheumatics; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Janus kinase 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Rheumatoid arthritis

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 01 Jul 2014 Vertex completes a phase IIb trial in Rheumatoid arthritis in USA, Argentina, Bulgaria, Czech Republic, Estonia, Germany, Hungary, Mexico, Poland, Romania, Russia, Serbia, Slovakia and Ukraine (NCT01590459) prior to July 2015
  • 01 Feb 2014 Vertex Pharmaceuticals completes a phase II trial in Rheumatoid arthritis in USA, South Africa, the Netherlands, Denmark, Lithuania & Estonia (NCT01754935)
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