CX 5461

Drug Profile

CX 5461

Alternative Names: CX-5461

Latest Information Update: 04 Jan 2018

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At a glance

  • Originator Cylene Pharmaceuticals
  • Developer BC Cancer Research Centre; Canadian Cancer Trials Group; Peter MacCallum Cancer Centre; Senhwa Biosciences
  • Class Amides; Antineoplastics; Heterocyclic compounds with 4 or more rings; Pyrazines; Small molecules; Thiazoles
  • Mechanism of Action RNA polymerase I inhibitors; Tumour suppressor protein p53 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Phase I Haematological malignancies

Most Recent Events

  • 09 Dec 2017 Efficacy, safety and pharmacokinetics data from a phase I trial in Haematological malignancies presented at the 59th Annual Meeting and Exposition of the American Society of Hematology (ASH-HEM 2017)
  • 01 May 2016 Phase-I/II clinical trials in Solid tumours (Late-stage disease) in Canada (IV) (NCT02719977)
  • 16 Apr 2016 Preclinical trials in Solid tumours and Haematological malignancies in Canada before April 2016 (Intraperitoneal)
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