Research programme: microRNA therapeutics - miRagen Therapeutics

Drug Profile

Research programme: microRNA therapeutics - miRagen Therapeutics

Alternative Names: AntimiR-15; AntimiR-155; AntimiR-208; AntimiRNA-15; LNA antimiR; MGN 7455; MGN-4893; miR-143/145; miR-15/195; miR-206; miR-208; miR-208/499; miR-29; miR-499; miR-92/126; miR-92a; MIRG-9103; miRNA-145 inhibitor; MRG 110; MRG-107

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator University of Texas Southwestern Medical Center
  • Developer miRagen Therapeutics; Servier; University of Glasgow; University of Texas Southwestern Medical Center
  • Class Cardiovascular therapies; MicroRNAs; Neuroprotectants
  • Mechanism of Action MicroRNA inhibitors; MIRN145-microRNA-inhibitors; RNA modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Polycythaemia vera
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Amyotrophic lateral sclerosis; Cardiovascular disorders; Hypertrophic cardiomyopathy; Ischaemia
  • No development reported Heart failure; Postmyocardial infarction
  • Discontinued Coronary artery restenosis; Fibrosis; Polycythaemia vera; Pulmonary arterial hypertension

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for preclinical development in Heart-failure in USA (Parenteral)
  • 03 May 2017 miRagen Therapeutics and Servier plan two phase I trials for MRG 110 for Cardiovascular disorders in the first half of 2018
  • 03 May 2017 Servier and Miragen Therapeutics extend collaboration through September 2019
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