Drug Profile


Alternative Names: LY-2157299

Latest Information Update: 23 Jul 2017

$50 / €47 *
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At a glance

  • Originator Eli Lilly
  • Developer AstraZeneca; Eli Lilly; National Cancer Institute (USA); Vanderbilt-Ingram Cancer Center; Weill Cornell Medical College
  • Class Antineoplastics; Pyrazoles; Pyridines; Pyrroles; Quinolines; Small molecules
  • Mechanism of Action Phosphotransferase inhibitors; Transforming growth factor beta1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Myelodysplastic syndromes
  • Phase II Breast cancer; Glioblastoma; Hepatocellular carcinoma; Pancreatic cancer; Rectal cancer
  • Phase I/II Glioma; Non-small cell lung cancer
  • Phase I Cancer; Solid tumours

Most Recent Events

  • 05 Jul 2017 University of Oklahoma and Eli Lilly plan a phase I trial for Ovarian cancer and Uterine cancer (Newly diagnosed, Combination therapy, Recurrent) (NCT03206177)
  • 02 Jun 2017 Adverse events and efficacy data from a phase II trial in Hepatocellular carcinoma presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 20 Mar 2017 University of Pennsylvania plans a phase I trial for Hepatocellular carcinoma (Late-stage disease, Second-line therapy or greater, Inoperable/unresectable) in USA (NCT03081377)
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