Resminostat - 4SC

Drug Profile

Resminostat - 4SC

Alternative Names: 4SC-201; BYK 408740; RAS 2410; YHI-1001

Latest Information Update: 07 Dec 2017

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At a glance

  • Originator Nycomed
  • Developer 4SC; Yakult Honsha
  • Class Antineoplastics; Dimethylamines; Hydroxylamines; Pyrroles; Small molecules; Sulfonamides
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma; Hodgkin's disease
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Biliary cancer; Hepatocellular carcinoma; Hodgkin's disease; Mycosis fungoides; Non-small cell lung cancer; Pancreatic cancer; Sezary syndrome
  • Phase I/II Colorectal cancer
  • Phase I Cutaneous T cell lymphoma
  • Preclinical Diffuse large B cell lymphoma
  • No development reported Solid tumours

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Second-line therapy or greater) in Japan (PO, Tablet)
  • 13 Sep 2017 Efficacy data from a phase I trial in Biliary cancer and Pancreatic cancer presented at the European Society for Medical Oncology (ESMO-2017)
  • 13 Sep 2017 Yakult Honsha plans a phase II trial (Second-line therapy) for Biliary cancer in Japan
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