Drug Profile


Alternative Names: AMG-888; U3-1287

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Amgen; U3 Pharma
  • Developer Daiichi Sankyo Company
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action ERBB-3 receptor antagonists; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II Breast cancer; Head and neck cancer
  • Phase I Solid tumours

Most Recent Events

  • 31 Dec 2016 Daiichi Sankyo completes a phase I trial for Non-small cell lung cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in Japan (JapicCTI152841)
  • 18 Jul 2016 Biomarkers information updated
  • 01 Jun 2016 Daiichi Sankyo completes phase-I clinical trials in Head and neck cancer (Combination therapy, Metastatic disease) in United Kingdom (IV) (NCT02350712)
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