PF 4447943

Drug Profile

PF 4447943

Alternative Names: PDE9i; PF-04447943; PF-4447943

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Pfizer
  • Class Neuropsychotherapeutics
  • Mechanism of Action Phosphodiesterase 9A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Sickle cell anaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Sickle cell anaemia
  • Discontinued Alzheimer's disease

Most Recent Events

  • 03 Dec 2016 Pharmacodynamics data from a preclinical study in Sickle cell anaemia presented at the 58th Annual Meeting and Exposition of the American Society of Hematology (ASH-2016)
  • 01 Oct 2016 Pfizer completes a phase I trial in Sickle cell anaemia (In volunteers) in USA (NCT02785770)
  • 01 Sep 2016 Pfizer completes a phase I trial in Sickle cell anaemia in USA, Belgium, Italy, the Netherlands and United Kingdom (PO) (NCT02114203)
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