Drug Profile


Alternative Names: ABT-888; NSC-737664

Latest Information Update: 18 Dec 2016

Price : $50

At a glance

  • Originator Abbott Laboratories; University of Alabama at Birmingham
  • Developer Abbott Laboratories; AbbVie; Georgetown University; Narodny onkologicky ustav; National Cancer Institute (USA); University of Alabama at Birmingham
  • Class Antineoplastics; Benzimidazoles; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; Non-small cell lung cancer; Ovarian cancer
  • Phase II/III Glioblastoma
  • Phase II Brain metastases; Colorectal cancer; Germ cell and embryonal neoplasms; Malignant melanoma; Pancreatic cancer; Rectal cancer; Solid tumours
  • Phase I/II Small cell lung cancer
  • Phase I Prostate cancer
  • Discontinued Hepatocellular carcinoma

Most Recent Events

  • 12 Dec 2016 AbbVie initiates an expanded-access programme for Breast cancer in the US (NCT02985658)
  • 28 Nov 2016 AbbVie suspended enrolment in a phase II/III trial for Glioblastoma in USA and Puerto Rico because the phase II part of the study met its accrual goal (NCT02152982)
  • 04 Nov 2016 Veliparib receives Orphan Drug status for Non-small cell lung cancer (Late-stage disease, Combination therapy) in USA
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