Niraparib - Merck/Janssen/TESARO

Drug Profile

Niraparib - Merck/Janssen/TESARO

Alternative Names: JNJ-64091742; MK-4827; niraparib hydrochloride; Zejula

Latest Information Update: 22 Nov 2017

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At a glance

  • Originator Merck & Co
  • Developer Bayer; Dana-Farber Cancer Institute; European Network of Gynaecological Oncological Trial Groups; European Organisation for Research and Treatment of Cancer; Georgetown University; Hoosier Cancer Research Network; Janssen; Merck & Co; Myriad Genetics; NeoGenomics; Resolution Bioscience; Sarcoma Alliance for Research through Collaboration; TESARO; Thomas Jefferson University; University of Utah
  • Class Antineoplastics; Benzamides; Indazoles; Piperidines; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase 1 inhibitors; Poly(ADP-ribose) polymerase 2 inhibitors; Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase III Breast cancer
  • Phase II Non-small cell lung cancer; Prostate cancer
  • Phase I Ewing's sarcoma; Solid tumours
  • No development reported Haematological malignancies

Most Recent Events

  • 01 Dec 2017 Tesaro plans a phase I trial for Solid tumours (Second-line therapy or greater) in USA in December 2017 (NCT03359850)
  • 20 Nov 2017 Registered for Fallopian tube cancer (Recurrent, Second-line therapy or greater) in Liechtenstein, Iceland, Norway, European Union (PO)
  • 20 Nov 2017 Registered for Ovarian cancer (Recurrent, Second-line therapy or greater) in Liechtenstein, Iceland, Norway, European Union (PO)
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