Pacritinib

Drug Profile

Pacritinib

Alternative Names: ENPAXIQ; ONX-0803; Pacritinibum; SB-1518

Latest Information Update: 20 Sep 2017

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At a glance

  • Originator S*BIO
  • Developer Cardiff University; CTI BioPharma; National Cancer Research Institute; Ohio State University Comprehensive Cancer Center; S*BIO; University of California, San Diego; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine; Weill Cornell Medical College
  • Class Antineoplastics; Macrocyclic compounds; Polycyclic bridged compounds; Pyrimidines; Pyrrolidines; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Interleukin-1 receptor-associated kinase inhibitors; Janus kinase-2 inhibitors; Macrophage colony stimulating factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myeloproliferative disorders; Myelofibrosis
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preregistration Myelofibrosis
  • Phase II Acute myeloid leukaemia; Myelodysplastic syndromes; Myeloproliferative disorders; Thrombocytopenia
  • Phase I/II Graft-versus-host disease
  • Phase I Haematological disorders
  • Preclinical Chronic myeloid leukaemia
  • Suspended Colorectal cancer
  • Discontinued Lymphoma

Most Recent Events

  • 18 Aug 2017 CTI Biopharma and HOVON foundation initiate enrolment in the phase II HOVON 134 MF trial for Myelofibrosis in Netherlands (PO) (EudraCT2015-000195-98)
  • 13 Jul 2017 Preregistration for Myelofibrosis in European Union (PO)
  • 06 Jul 2017 CTI BioPharma suspends patient enrolment in a phase I trial as per FDA in Acute myeloid leukaemia (Combination therapy) in USA (PO) (NCT02323607)
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