PF 04457845

Drug Profile

PF 04457845

Alternative Names: PF-04457845; PF-4457845

Latest Information Update: 28 Sep 2017

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At a glance

  • Originator Pfizer
  • Developer Linkoping University; Pfizer; SpringWorks Therapeutics; Stockholm Centre for Dependency Disorders
  • Class Benzylidene compounds; Piperidines; Pyridazines; Small molecules
  • Mechanism of Action Fatty acid amide hydrolase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Psychiatric disorders
  • Discontinued Alcoholism; Pain; Post-traumatic stress disorders

Most Recent Events

  • 25 Sep 2017 SpringWorks Therapeutics, a Pfizer spinoff is developing PF 04457845
  • 28 Feb 2017 Phase-II clinical trials in Psychiatric disorders (In volunteers) in Sweden (PO) (EudraCT2016-005013-47)
  • 28 Oct 2015 Discontinued - Phase-II for Alcoholism in Sweden (PO)
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