Drug Profile


Alternative Names: 4-Demethyl-4-cholesteryloxycarbonylpenclomedine; Penclomidine derivative

Latest Information Update: 12 May 2017

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At a glance

  • Originator Dekk-Tec
  • Class Antineoplastics; Carbonates; Picolines
  • Mechanism of Action Alkylating agents; Cell cycle modulators; Cell death stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Brain cancer; Brain metastases
  • Phase I Cancer; Solid tumours

Most Recent Events

  • 01 Apr 2017 Efficacy data from preclinical, phase I, and phase II trials in Solid tumours (including brain cancer/metastases)presented at the 107th Annual Meeting of the American Association for Cancer Research (AACR - 2017)
  • 31 Aug 2016 Dekk-Tec plans a phase II trial for Cancer (Late-stage disease, Second-line therapy or greater, In infants, In children, In adolescents) in USA (IV) (NCT02889445)
  • 01 Jun 2016 Dekk-Tec completes a phase II trial in Brain metastases and Brain cancer in USA (NCT02038218)
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