Brexpiprazole

Drug Profile

Brexpiprazole

Alternative Names: Lu-AF41156; OPC-34712; OPDC-34712; Rexulti

Latest Information Update: 10 Jan 2017

Price : $50

At a glance

  • Originator Otsuka Pharmaceutical Development & Commercialization
  • Developer Lundbeck A/S; Otsuka Pharmaceutical Development & Commercialization
  • Class Antidepressants; Antipsychotics; Behavioural disorder therapies; Piperazines; Quinolines; Small molecules
  • Mechanism of Action Alpha 1 adrenergic receptor antagonists; Alpha 2c adrenergic receptor antagonists; Dopamine D2 receptor partial agonists; Serotonin 1A receptor partial agonists; Serotonin 2A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Major depressive disorder; Schizophrenia
  • Phase III Agitation; Post-traumatic stress disorders; Sleep disorders
  • Discontinued Attention-deficit hyperactivity disorder

Most Recent Events

  • 06 Jan 2017 Preregistration for Schizophrenia in Japan (PO)
  • 15 Nov 2016 Otsuka Pharmaceutical Development & Commercialization and Lundbeck plan a phase I trial for Schizophrenia in USA (IV and SC, Injection) (NCT02968121)
  • 02 Nov 2016 Investigation in Schizophrenia in USA (IV) before November 2016
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