Siponimod

Drug Profile

Siponimod

Alternative Names: BAF-312

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Novartis
  • Class Azetidines; Carboxylic acids; Immunotherapies; Small molecules
  • Mechanism of Action Sphingosine 1 phosphate receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Multiple sclerosis
  • Phase II Dermatomyositis; Polymyositis
  • Phase I Liver failure; Renal failure

Most Recent Events

  • 31 May 2017 Novartis intends to make regulatory submissions for siponimod for secondary progressive Multiple sclerosis in 2018
  • 22 Apr 2017 Adverse events data from the phase III EXPAND study in Multiple sclerosis presented at the 69th Annual Meeting of the American Academy of Neurology (AAN 2017)
  • 21 Apr 2017 Interim immunogenicity data from a phase III AMS04 trial in Multiple sclerosis presented at the (69th Annual Meeting of the American Academy of Neurology (AAN-2017)
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