Drug Profile


Alternative Names: PF-04554878; PF-4554878; VS-6063

Latest Information Update: 11 Jan 2017

Price : $50

At a glance

  • Originator Pfizer
  • Developer Pfizer; Verastem; Washington University
  • Class Antineoplastics; Benzamides; Pyrazines; Pyrimidines; Small molecules; Sulfones
  • Mechanism of Action Focal adhesion protein-tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Mesothelioma
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Mesothelioma; Non-small cell lung cancer
  • Phase I Cancer; Pancreatic cancer; Solid tumours
  • Preclinical Breast cancer
  • No development reported Ovarian cancer

Most Recent Events

  • 30 Sep 2016 Verastem, Merck Sharpe & Dohme and Cancer Research UK to co-develop defactinib and pembrolizumab for Mesothelioma, Non-small cell lung and Pancreatic cancer
  • 30 Sep 2016 Verastem and MSD plans a phase Ib/IIa trial for Cancer in the UK
  • 16 Jul 2016 No recent reports of development identified for phase-I development in Ovarian-cancer(Combination therapy, Late-stage disease) in USA (PO, Tablet)
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