Drug Profile


Alternative Names: Defactinib hydrochloride; PF-04554878; PF-4554878; VS-6063

Latest Information Update: 14 Jul 2017

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At a glance

  • Originator Pfizer
  • Developer Cancer Research UK; Pfizer; Verastem; Washington University
  • Class Antineoplastics; Benzamides; Pyrazines; Pyrimidines; Small molecules; Sulfones
  • Mechanism of Action Focal adhesion protein-tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Mesothelioma; Non-small cell lung cancer
  • Phase I/II Ovarian cancer; Solid tumours
  • Phase I Cancer; Pancreatic cancer
  • Preclinical Breast cancer

Most Recent Events

  • 23 Sep 2017 University of California plans the ROCKIF phase I/II trial for Ovarian cancer (Second-line therapy) (NCT03287271)
  • 02 Jun 2017 Efficacy and adverse events data from a phase II Window of Opportunity trial in Mesothelioma presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 01 May 2017 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Combination therapy, Second-line therapy or greater) in United Kingdom (PO) (NCT02758587)
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