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Resmetirom - Madrigal Pharmaceuticals

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Drug Profile

Resmetirom - Madrigal Pharmaceuticals

Alternative Names: MGL-3196; Rezdiffra; VIA-3196

Latest Information Update: 19 Jan 2026

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At a glance

  • Originator Roche
  • Developer Madrigal Pharmaceuticals
  • Class Antihyperglycaemics; Antihyperlipidaemics; Chlorinated hydrocarbons; Ethers; Hepatoprotectants; Ketones; Nitriles; Pyridazines; Small molecules; Triazines
  • Mechanism of Action Thyroid hormone receptor beta agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-alcoholic steatohepatitis
  • Discontinued Hyperlipoproteinaemia type IIa

Most Recent Events

  • 29 Dec 2025 Madrigal Pharmaceuticals initiates enrolment in a phase II trial for Non-alcoholic steatohepatitis in USA and Canada (NCT07335601)
  • 10 Nov 2025 Efficacy data from the phase-III MAESTRO-NASH trial in Non-alcoholic steatohepatitis released by Madrigal
  • 10 Nov 2025 Pharamcodynamics, efficacy and adverse events data from phase III MAESTRO-NAFLD-1 trial in Non-alcoholic steatohepatitis released by Madrigal Pharmaceuticals

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