Drug Profile


Alternative Names: ACE-536

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Acceleron Pharma
  • Developer Acceleron Pharma; Celgene Corporation
  • Class Antianaemics; Disulfides; Immunoglobulin Fc fragments; Peptides; Recombinant fusion proteins
  • Mechanism of Action TGF-beta superfamily protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Beta-thalassaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Beta-thalassaemia; Myelodysplastic syndromes
  • Phase II Anaemia; Myelofibrosis
  • Preclinical Sickle cell anaemia

Most Recent Events

  • 03 Aug 2017 Acceleron and Celgene plan the phase II BEYOND trial for Beta-thalassaemia by year-end 2017
  • 03 Aug 2017 Celgene initiates a phase II trial in Myelofibrosis and Anaemia (SC) before August 2017
  • 23 Jun 2017 Interim efficacy and adverse events data from a phase II trial in Beta-thalassaemia presented at the 22nd Congress of the European Hematology Association (EHA-2017)
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