Luspatercept - Acceleron Pharma/Celgene Corporation

Drug Profile

Luspatercept - Acceleron Pharma/Celgene Corporation

Alternative Names: ACE-536

Latest Information Update: 15 Dec 2017

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At a glance

  • Originator Acceleron Pharma
  • Developer Acceleron Pharma; Celgene Corporation
  • Class Antianaemics; Disulfides; Immunoglobulin Fc fragments; Peptides; Recombinant fusion proteins
  • Mechanism of Action TGF-beta superfamily protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Beta-thalassaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Beta-thalassaemia; Myelodysplastic syndromes
  • Phase II Anaemia; Myelofibrosis
  • Preclinical Sickle cell anaemia

Most Recent Events

  • 10 Dec 2017 Pooled efficacy and adverse events data from the phase II trials in Myelodysplastic syndrome presented at the 59th Annual Meeting of the American Society of Hematology (ASH-Hem-2017)
  • 07 Nov 2017 Acceleron and Celgene plans seven clinical trials in 2018
  • 07 Nov 2017 Acceleron plans a phase II trial for Myelofibrosis by year end 2017
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