Autologous tumour cell vaccine - Champions Oncology/Gradalis/Mary Crowley

Drug Profile

Autologous tumour cell vaccine - Champions Oncology/Gradalis/Mary Crowley

Alternative Names: Bi-shRNAfurin; FANG vaccine; TAG vaccine; TGFbeta2 antisense + rhGMCSF vaccine; Vigil EATC; Vigil™

Latest Information Update: 03 Jan 2017

Price : $50

At a glance

  • Originator Gradalis
  • Developer Gradalis; Mary Crowley Cancer Research Center
  • Class Cancer vaccines; Tumour cell vaccines
  • Mechanism of Action Furin expression inhibitors; Granulocyte-macrophage colony-stimulating factor expression stimulants; Immunostimulants; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase III Ovarian cancer
  • Phase II/III Breast cancer
  • Phase II Ewing's sarcoma; Liver metastases; Malignant melanoma; Non-small cell lung cancer
  • Phase I Solid tumours

Most Recent Events

  • 21 Dec 2016 Gradalis and Genentech agree to co-develop autologous tumour cell vaccine combined with atezolizumab in USA for Ovarian cancer
  • 21 Dec 2016 Gradalis plans a phase II trial for Ovarian cancer in USA
  • 01 Dec 2016 Mary Crowley Cancer Research Center completes a phase I trial in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (NCT00684294)
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