Drug Profile


Alternative Names: AB-1010; Masican; Masitinib mesilate; Masitinib mesylate; Masiviera

Latest Information Update: 27 Mar 2017

Price : $50

At a glance

  • Originator AB Science
  • Class Antiasthmatics; Antineoplastics; Antirheumatics; Benzamides; Nootropics; Piperazines; Pyridines; Small molecules; Thiazoles
  • Mechanism of Action Colony stimulating factor inhibitors; Focal adhesion protein-tyrosine kinase inhibitors; Platelet derived growth factor alpha receptor antagonists; Platelet-derived growth factor receptor antagonists; Protein tyrosine kinase inhibitors; Proto oncogene protein c-kit inhibitors; Type 3 fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mastocytosis; Gastrointestinal stromal tumours; Amyotrophic lateral sclerosis; Gastric cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Amyotrophic lateral sclerosis; Mastocytosis
  • Phase III Alzheimer's disease; Asthma; Colorectal cancer; Gastrointestinal stromal tumours; Malignant melanoma; Multiple myeloma; Pancreatic cancer; Peripheral T-cell lymphoma; Prostate cancer
  • Phase II/III Crohn's disease; Multiple sclerosis; Ovarian cancer; Progressive supranuclear palsy
  • Phase II Breast cancer; Chronic obstructive pulmonary disease; Head and neck cancer; Mood disorders; Non-small cell lung cancer; Parkinson's disease
  • Phase I/II Gastric cancer; Glioblastoma; Hepatocellular carcinoma; Oesophageal cancer
  • Preclinical Stroke
  • No development reported Psoriasis
  • Discontinued Rheumatoid arthritis

Most Recent Events

  • 27 Jan 2017 AB Science suspends a phase-III trial in Asthma in USA, France Hungary Belgium, Czech Republic, Bulgaria, Germany, Slovakia, Spain, Greece, India, Thailand (PO) (CTRI/2011/11/002122)
  • 16 Dec 2016 AB Science terminates a phase-III trial in Colorectal cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in India, Canada, Czech Republic, France, Greece, Hungary, Slovakia, Spain and United Kingdom (PO) (CTRI/2015/10/006331)
  • 05 Nov 2016 AB Science completes a phase II trial in Parkinson's disease in Slovakia (EudraCT2010-024424-26)
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