Rebastinib

Drug Profile

Rebastinib

Alternative Names: DCC-2036; DP-1919; DP-1919.TO

Latest Information Update: 24 Aug 2016

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At a glance

  • Originator Deciphera Pharmaceuticals
  • Developer Albert Einstein College of Medicine; Deciphera Pharmaceuticals
  • Class Antineoplastics; Quinolines; Small molecules; Urea compounds
  • Mechanism of Action Bcr-abl tyrosine kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors; Lyn protein-tyrosine kinase inhibitors; Proto-oncogene protein c-hck inhibitors; TIE 2 receptor antagonists; TrkA receptor antagonists; Vascular endothelial growth factor receptor-1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Chronic myeloid leukaemia
  • Phase I Breast cancer

Most Recent Events

  • 19 Jul 2016 Deciphera Pharmaceuticals and Montefiore Medical Center plan a phase I trial in Breast cancer (Late-stage disease; Combination therapy, Second-line therapy or greater) in USA (PO) (NCT02824575)
  • 01 Jul 2016 Phase-I clinical trials in Breast cancer (Late-stage disease, Combination therapy, Second-line therapy or greater) in USA (PO) (NCT02824575)
  • 22 Sep 2015 Phase-I/II development for Leukaemia (Acute lymphoblastic leukaemia, chronic myeloid leukaemia and acute myeloid leukaemia) completed in USA and Australia
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