Lurbinectedin

Drug Profile

Lurbinectedin

Alternative Names: PM-01183; PM-1183; Tryptamicidin

Latest Information Update: 22 May 2017

Price : $50

At a glance

  • Originator PharmaMar
  • Developer Fundacion Instituto Valenciano de Oncologia; PharmaMar
  • Class 3-ring heterocyclic compounds; Acetates; Alkaloids; Antineoplastics; Dioxolanes; Indoles; Small molecules
  • Mechanism of Action Alkylating agents; Apoptosis stimulants; Cell cycle inhibitors; RNA polymerase II inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Ovarian cancer; Small cell lung cancer
  • Phase II Breast cancer; Non-small cell lung cancer; Pancreatic cancer; Sarcoma; Solid tumours
  • Phase I Leukaemia

Most Recent Events

  • 18 May 2017 Specialised Therapeutics Asia in-licences marketing rights for lurbinectedin in Australia, New Zealand, Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Papua New Guinea, Philippines, Singapore, Timor-Leste, Thailand and Vietnam
  • 01 Jan 2017 PharmaMar completes a phase I trial for Solid tumours (Combination therapy) in United Kingdom and Switzerland (NCT01980667)
  • 22 Dec 2016 Lurbinectedin licensed to Chugai Pharmaceutical in Japan
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