Drug Profile


Alternative Names: GSK-2141795; GSK-2141795C; GSK-795

Latest Information Update: 10 Feb 2017

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At a glance

  • Originator GlaxoSmithKline
  • Developer Dana-Farber Cancer Institute; GlaxoSmithKline; National Cancer Institute (USA); National Comprehensive Cancer Network; University of California at San Francisco
  • Class Amides; Antineoplastics; Furans; Pyrazoles; Small molecules
  • Mechanism of Action Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Breast cancer; Cervical cancer; Endometrial cancer; Malignant melanoma; Multiple myeloma; Uveal melanoma
  • No development reported Lymphoma; Ovarian cancer; Solid tumours

Most Recent Events

  • 03 Dec 2016 Efficacy data from a phase II trial in Multiple myeloma (Combination therapy, Second-line therapy or greater) presented at the 58th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2016)
  • 10 Aug 2016 Novartis terminates a phase II trial in Cervical cancer (Combination therapy, Recurrent) in USA due to reasons related to drug supply (NCT01958112)
  • 16 Jul 2016 No recent reports of development identified for phase-I development in Lymphoma(Monotherapy) in Canada (PO)
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