Drug Profile


Alternative Names: Tepadina; Thioplex

Latest Information Update: 14 Aug 2017

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At a glance

  • Originator ADIENNE
  • Developer ADIENNE; Amneal Pharmaceuticals; Gruppo Italiano Trapianto di Midollo Osseo; RIEMSER Arzneimittel
  • Class Antineoplastics; Myeloablative agonists; Organothiophosphorus compounds
  • Mechanism of Action Alkylating agents; DNA synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Haematological disorders
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Adenocarcinoma; Cancer metastases; Graft-versus-host disease; Haematological disorders; Papilloma; Solid tumours
  • Clinical Phase Unknown Brain cancer

Most Recent Events

  • 30 Jun 2017 Adienne completes the phase II Gandalf-01 trial in Acute lymphoblastic leukaemia and Acute myeloid leukaemia (Second-line therapy or greater) and Graft-versus-host disease (Prevention) in Italy (IV) (NCT01814488)
  • 01 May 2017 Clinical trials in Brain cancer (In children, In infants, In neonates, In adolescents, Combination therapy) in Japan (IV) (UMIN000026084)
  • 27 Apr 2017 Thiotepa licensed to Amneal Pharmaceuticals in USA
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