Drug Profile


Alternative Names: Dual TORC1/2 inhibitor - Millennium Pharmaceuticals; HY 13328; INK 128; MLN-0128; Oral mTORC1/2 inhibitor MLN0128 - Millennium Pharmaceuticals; TAK 228

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Intellikine
  • Developer Dana-Farber Cancer Institute; European Network for Translational Research in Ovarian Cancer (EUTROC); National Cancer Institute (USA); Takeda; Takeda Oncology
  • Class Antineoplastics; Benzoxazoles; Pyrazolones; Pyrimidines; Small molecules
  • Mechanism of Action MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Bladder cancer; Breast cancer; Endometrial cancer; Glioblastoma; Neuroendocrine tumours; Renal cell carcinoma; Soft tissue sarcoma; Thyroid cancer
  • Phase I/II Liver cancer; Merkel cell carcinoma; Sarcoma
  • No development reported Solid tumours
  • Discontinued Multiple myeloma; Non-small cell lung cancer; Prostate cancer; Waldenstrom's macroglobulinaemia

Most Recent Events

  • 06 Jul 2017 Takeda, in collaboration with M.D. Anderson Cancer Center plans a phase I trial for Lymphoma (Combination therapy, Second-line therapy or greater) in USA (NCT03205891)
  • 19 Jun 2017 Baylor Research Institute and Takeda initiate enrolment in a phase II trial for Breast cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in USA (PO) (NCT03193853)
  • 18 May 2017 Avera McKennan Hospital & University Health Center plans a phase I trial for Solid tumours (Late-stage disease, Combination therapy) in USA (NCT03154294)
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