Sapanisertib - Takeda Oncology

Drug Profile

Sapanisertib - Takeda Oncology

Alternative Names: HY-13328; INK-128; MLN-0128; TAK-228

Latest Information Update: 28 Nov 2017

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At a glance

  • Originator Intellikine
  • Developer Dana-Farber Cancer Institute; European Network for Translational Research in Ovarian Cancer (EUTROC); National Cancer Institute (USA); Takeda; Takeda Oncology
  • Class Antineoplastics; Benzoxazoles; Pyrazolones; Pyrimidines; Small molecules
  • Mechanism of Action MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Bladder cancer; Breast cancer; Endometrial cancer; Glioblastoma; Neuroendocrine tumours; Renal cell carcinoma; Soft tissue sarcoma; Thyroid cancer
  • Phase I/II Liver cancer; Merkel cell carcinoma; Sarcoma
  • Phase I Solid tumours
  • Discontinued Multiple myeloma; Non-small cell lung cancer; Prostate cancer; Waldenstrom's macroglobulinaemia

Most Recent Events

  • 26 Oct 2017 Pharmacokinetics, efficacy and adverse events data from a phase Ib trial in Solid tumours presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics (AACR-NCI-EORTC-2017)
  • 06 Jul 2017 Takeda, in collaboration with M.D. Anderson Cancer Center plans a phase I trial for Lymphoma (Combination therapy, Second-line therapy or greater) in USA (NCT03205891)
  • 29 Jun 2017 Phase-II clinical trials in Renal cell carcinoma (Metastatic disease, Second-line therapy or greater, Monotherapy) in USA (PO) (NCT03097328)
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