Drug Profile


Alternative Names: Allogeneic ex-vivo expanded placental adherent stromal cells; Allogeneic mesenchymal-like adherent stromal cells; PLacental eXpanded cells; PLX-PAD cell therapy

Latest Information Update: 19 Sep 2017

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At a glance

  • Originator Pluristem Therapeutics
  • Class Ischaemic heart disorder therapies; Stem cell therapies; Vascular disorder therapies
  • Mechanism of Action Cell differentiation modulators; Cell replacements; Dendritic cell modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Preeclampsia; Thromboangiitis obliterans
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Peripheral arterial disorders
  • Phase II Intermittent claudication; Muscle injury
  • Phase I Pulmonary arterial hypertension
  • Preclinical Duchenne muscular dystrophy; Ischaemic heart disorders; Preeclampsia; Tendon injuries

Most Recent Events

  • 18 Sep 2017 PLX PAD receives Fast Track designation for Peripheral arterial disorders [IM,Injection] (In the elderly, In adults) in USA
  • 13 Sep 2017 Pluristem Therapeutics has patent protection for placental expanded (PLX) cells for the treatment of Critical limb ischaemia and muscle regeneration in Hong Kong
  • 11 Sep 2017 Phase-III clinical trials in Peripheral arterial disorders (In adults, In the elderly) in Austria (IM), before September 2017 (NCT03006770)
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