Gedatolisib

Drug Profile

Gedatolisib

Alternative Names: PF-05212384; PF-5212384; PKI-587

Latest Information Update: 15 Feb 2017

Price : $50

At a glance

  • Originator Wyeth
  • Developer Curie Institute; Eastchester Center for Cancer Care; Netherlands Cancer Institute; Pfizer
  • Class Antineoplastics; Morpholines; Piperidines; Small molecules; Triazines; Urea compounds
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTOR protein inhibitors; MTORC1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Colorectal cancer; Non-small cell lung cancer
  • Phase I Breast cancer; Solid tumours
  • Discontinued Endometrial cancer

Most Recent Events

  • 28 Sep 2016 Pfizer and University of Florida plan a phase Ib/II trial for Non-small cell lung cancer (Combination therapy, Metastatic disease, Late-stage disease, Inoperable/Unresectable, Second-line therapy or greater) in USA (IV) (NCT02920450)
  • 01 Jun 2016 Phase-I clinical trials in Breast cancer (Combination therapy, Late-stage disease, Metastatic disease) in USA (IV) (NCT02684032)
  • 15 Mar 2016 Biomarkers information updated
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