Drug Profile


Alternative Names: PF-05212384; PF-5212384; PKI-587

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Wyeth
  • Developer Curie Institute; Eastchester Center for Cancer Care; Netherlands Cancer Institute; Pfizer; University of Florida
  • Class Antineoplastics; Morpholines; Piperidines; Small molecules; Triazines; Urea compounds
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTOR protein inhibitors; MTORC1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Colorectal cancer; Non-small cell lung cancer
  • Phase I Breast cancer; Solid tumours
  • Discontinued Endometrial cancer

Most Recent Events

  • 14 Aug 2017 Indiana University plans a phase I trial for Breast cancer (Metastatic disease, Second-line therapy or greater, Combination therapy) in USA (NCT03243331)
  • 18 May 2017 Phase-I/II clinical trials in Non-small cell lung cancer (Combination therapy, Inoperable/Unresectable, Metastatic disease, Late-stage disease) in USA (IV) (NCT02920450)
  • 28 Feb 2017 Phase-I clinical trials in Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in USA (IV) (NCT03065062)
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