Drug Profile


Alternative Names: H4R antagonist; Histamine 4 Receptor antagonist; JNJ-168; JNJ-38518168; JNJ-38518168-ZBQ

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Johnson & Johnson Pharmaceutical Research & Development
  • Developer Janssen Research & Development
  • Class Antiasthmatics; Antihistamines; Antipruritics; Antipsoriatics; Antirheumatics; Benzimidazoles; Diaminopyrimidines; Piperidines; Small molecules
  • Mechanism of Action Histamine H4 receptor antagonists; Th1 cell modulators; Th17 cell modulators; Th2 cell modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Asthma; Plaque psoriasis; Rheumatoid arthritis
  • No development reported Pruritus

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 16 Jul 2016 No recent reports of development identified for phase-I development in Rheumatoid-arthritis(In volunteers) in Belgium (PO, Liquid)
  • 16 Jul 2016 No recent reports of development identified for preclinical development in Pruritus in USA
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