Drug Profile


Alternative Names: Anti-Delta-Like Ligand 4 monoclonal antibody - Regeneron; Anti-DLL4 monoclonal antibody - Regeneron; REGN-421; SAR-153192

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Regeneron Pharmaceuticals; sanofi-aventis
  • Developer Regeneron Pharmaceuticals; Sanofi
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action DLL4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 31 Dec 2014 Discontinued - Phase-I for Solid tumours (Late-stage disease) in USA (IV) before December 2014 (Regeneron, Form 10-K, February 2015)
  • 31 Jul 2014 Sanofi opts out of co-development agreement for Enoticumab (ADNM)
  • 11 Mar 2014 Phase-I development is ongoing in USA
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