Research programme: HDAC6 inhibitors - Celgene

Drug Profile

Research programme: HDAC6 inhibitors - Celgene

Alternative Names: ACY 1083; ACY-738

Latest Information Update: 17 Jan 2017

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At a glance

  • Originator Dana-Farber Cancer Institute; Harvard University
  • Developer Acetylon Pharmaceuticals; Celgene Corporation
  • Class Small molecules
  • Mechanism of Action HDAC6 protein inhibitors; Histone deacetylase inhibitors; Interleukin 10 inhibitors; Programmed cell death 1 ligand 2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cardiovascular disorders; Charcot-Marie-Tooth disease; Chronic lymphocytic leukaemia; Depressive disorders; Diabetes mellitus; Neurological disorders; Stroke
  • No development reported Autoimmune disorders; Haematological malignancies

Most Recent Events

  • 16 Jul 2016 No recent reports of development identified for preclinical development in Autoimmune-disorders in USA (PO)
  • 16 Jul 2016 No recent reports of development identified for preclinical development in Haematological-malignancies in USA (PO)
  • 01 Apr 2016 Preclinical trials in Chronic lymphocytic leukaemia in USA (unspecified route)
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