AT 406

Drug Profile

AT 406

Alternative Names: AT-406; Debio-1143; SMAC mimetic - Debio-1143

Latest Information Update: 27 Oct 2016

Price : $50

At a glance

  • Originator Ascenta Therapeutics
  • Developer 3SBio; Ascenta Therapeutics; Debiopharm Group; The Leukemia & Lymphoma Society
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Inhibitor of apoptosis protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Head and neck cancer; Ovarian cancer
  • Phase I Breast cancer; Non-small cell lung cancer; Solid tumours
  • No development reported Acute myeloid leukaemia; Lymphoma
  • Discontinued Leukaemia

Most Recent Events

  • 24 Oct 2016 Debiopharm, Merck and Pfizer plan a phase I/Ib trial for Non-small cell lung cancer (Combination therapy, Metastatic disease, Late-stage disease)
  • 20 Oct 2016 Debiopharm, Merck and Pfizer enter into a collaboration agreement for a phase I/Ib trial of AT 406 for Non-small cell lung cancer
  • 16 Jul 2016 No recent reports of development identified for phase-I development in Lymphoma in USA (PO)
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