CDX 1401

Drug Profile

CDX 1401

Alternative Names: CDX-1401; DEC-205/NY-ESO-1 vaccine - Celldex

Latest Information Update: 09 Oct 2017

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At a glance

  • Originator Ludwig Institute for Cancer Research
  • Developer Celldex Therapeutics Inc; National Cancer Institute (USA); Roswell Park Cancer Institute
  • Class Cancer vaccines; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action DEC-205 receptor agonists; Dendritic cell stimulants; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma
  • Phase I/II Fallopian tube cancer; Gynaecological cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 06 Jul 2017 National Cancer Institute plans a phase I/II trial for Fallopian tube cancer (Recurrent, Second-line therapy or greater, Combination therapy),Ovarian cancer (Recurrent, Second-line therapy or greater, Combination therapy) and Peritoneal cancer (Recurrent, Second-line therapy or greater, Combination therapy) in USA (NCT03206047)
  • 03 Dec 2016 Accrued efficacy data from a phase I trial in Myelodysplastic syndromes and Acute myeloid leukaemia presented at the 58th Annual Meeting and Exposition of the American Society of Haematology (ASH-2016)
  • 29 Jul 2016 Case Comprehensive Cancer Center plans a phase I/II trial in Solid tumours (Combination therapy, Late-stage disease) in USA (NCT02661100)
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