CDX 1401

Drug Profile

CDX 1401

Alternative Names: CDX-1401; DEC-205/NY-ESO-1 vaccine - Celldex

Latest Information Update: 08 Dec 2017

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At a glance

  • Originator Ludwig Institute for Cancer Research
  • Developer Celldex Therapeutics Inc; National Cancer Institute (USA); Roswell Park Cancer Institute
  • Class Cancer vaccines; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action DEC-205 receptor agonists; Dendritic cell stimulants; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma
  • Phase I/II Fallopian tube cancer; Gynaecological cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 08 Dec 2017 CDX 1401 is still in phase I trials for Myelodysplastic syndromes (combination therapy, Second line therapy or greater) in USA
  • 08 Dec 2017 CDX 1401 is still in phase I trials for Acute myeloid leukaemia (combination therapy, Second line therapy or greater) in USA
  • 08 Dec 2017 Roswell Park Cancer Institute in collaboration with National Cancer Institute plans a phase I trial in Acute myeloid leukaemia and Myelodysplastic syndromes (Combination therapy) in USA (NCT03358719) (Trial profile 700290998)
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