Drug Profile


Alternative Names: Anti-EGFL7 - Genentech; M-444A; M0444A; MEGF-0444A; RG-7414; RO-5490248

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action EGFL7 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Colorectal cancer; Non-small cell lung cancer; Solid tumours

Most Recent Events

  • 17 Oct 2013 Discontinued - Phase-I for Solid tumours (combination therapy, late-stage disease, second-line therapy or greater) in USA (IV)
  • 17 Oct 2013 Discontinued - Phase-I for Solid tumours (monotherapy) in USA (IV)
  • 17 Oct 2013 Discontinued - Phase-I for Solid tumours in Japan (IV)
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