Drug Profile


Alternative Names: BGJ-398; NVP-BGJ398

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Novartis
  • Developer Array BioPharma; Novartis; Novartis Oncology
  • Class Aniline compounds; Antineoplastics; Methylurea compounds; Piperazines; Pyrimidines; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cholangiocarcinoma; Haematological malignancies
  • Discontinued Bladder cancer; Glioblastoma; Malignant melanoma; Solid tumours

Most Recent Events

  • 02 Jun 2017 Efficacy and adverse events data from a phase I trial in Solid tumours presented at the 53rd Annual Meeting of American Society of Clinical Oncology (ASCO-2017)
  • 01 Apr 2017 Pharmacodynamics and efficacy data from a phase II trial in Cholangiocarcinoma presented at the 108th Annual Meeting of the American Association for Cancer Research (AACR-2017)
  • 27 Jan 2017 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease) in France, Canada, Belgium, Singapore, Spain, USA, Australia, Germany, Netherlands, Switzerland, South Korea, Italy (PO) (Novartis 20-F filed in 2017)
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