Research programme: human histone methyltransferase inhibitors - Epizyme/GlaxoSmithKline

Drug Profile

Research programme: human histone methyltransferase inhibitors - Epizyme/GlaxoSmithKline

Alternative Names: DOT1L inhibitors - Epizyme; EPZ 01566; EPZ 015666; HDAC inhibitors - Epizyme; HMT inhibitors - Epizyme; HMT3 inhibitors - Epizyme; WHSC1 inhibitors - Epizyme

Latest Information Update: 10 Dec 2014

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At a glance

  • Originator Epizyme
  • Class Small molecules
  • Mechanism of Action DNA methylation inhibitors; Histone deacetylase inhibitors; Histone methyltransferase inhibitors; Protein methyltransferase modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cancer; Haematological malignancies; Leukaemia; Mantle-cell lymphoma; Non-Hodgkin's lymphoma

Most Recent Events

  • 08 Dec 2014 Pharmacodynamics data from a preclinical trial in Mantle cell lymphoma released by Epizyme
  • 28 Oct 2014 Preclinical development is ongoing in USA
  • 14 Mar 2012 Epizyme receives funds from The Leukaemia & Lymphoma Society for DOT1L-targeted histone methyltransferase inhibitor development in Leukaemia
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