Ceftolozane/tazobactam

Drug Profile

Ceftolozane/tazobactam

Alternative Names: CXA-101/tazobactam; CXA-201; MK-7625A; Tazobactam/ceftolozane; Tazobactam/CXA-101; Zerbaxa

Latest Information Update: 04 Oct 2017

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At a glance

  • Originator Astellas Pharma
  • Developer Cubist Pharmaceuticals; Merck Sharp & Dohme
  • Class 2 ring heterocyclic compounds; Antibacterials; Cephalosporins; Small molecules; Sulfones; Triazoles
  • Mechanism of Action Beta lactamase inhibitors; Cell wall inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gram-negative infections; Intra-abdominal infections; Urinary tract infections
  • Registered Pyelonephritis
  • Phase III Nosocomial pneumonia

Most Recent Events

  • 05 Sep 2017 Merck Sharp & Dohme completes a phase III trial in Urinary tract infections in Japan (IV) (NCT02728089)
  • 28 Jul 2017 Merck plans a phase II trial for Urinary tract infection (In neonates, In infants, In children, In adolescents) (NCT03230838)
  • 28 Jul 2017 Merck Sharp & Dohme completes a phase III trial for Intra-abdominal infections (Combination therapy) in Japan (IV) (NCT02739997)
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