Ceftolozane/tazobactam

Drug Profile

Ceftolozane/tazobactam

Alternative Names: CXA-101/tazobactam; CXA-201; MK-7625A; Tazobactam/ceftolozane; Tazobactam/CXA-101; TOL/TAZ; Zerbaxa

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Astellas Pharma
  • Developer Cubist Pharmaceuticals; Merck Sharp & Dohme
  • Class 2 ring heterocyclic compounds; Antibacterials; Cephalosporins; Small molecules; Sulfones; Triazoles
  • Mechanism of Action Beta lactamase inhibitors; Cell wall inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    Nosocomial pneumonia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gram-negative infections; Intra-abdominal infections; Urinary tract infections
  • Registered Pyelonephritis
  • Phase III Nosocomial pneumonia

Most Recent Events

  • 11 Apr 2016 Merck Sharp & Dohme plans a phase III trial for Intra-abdominal infections (Combination therapy) in Japan (IV) (NCT02739997)
  • 01 Apr 2016 Phase-III clinical trials in Intra-abdominal infections (Combination therapy) in Japan (IV) (NCT02739997)
  • 01 Apr 2016 Phase-III clinical trials in Urinary tract infections in Japan (IV) (NCT02728089)
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